In musical domain, pitch change (frequency change) within chromatic scale is generally named as "out of tune" or "mistune," and pitch change within diatonic scale is named as "out of key." Two different pitches form intervals, including melodic interval (tones played sequentially) and harmonic interval (tones played simultaneously).
And even as the body struggles to cope, faulty adjustments in sodium channel profiles mistune neurons to fire inappropriately, leading to additional problems.
(9) The therapeutic relation becomes defined musically: the therapist uses the piano, and mistunes a note, as a way of performing and discussing what it means to be out of tune with clients.