mir

"Ach, Herr Carey, Sie mussen mir nicht du sagen--you mustn't talk to me in the second person singular."

0ne night, a very long time ago, I drove to an Indian military cantonment called Mian Mir to see amateur theatricals.

'They would have flung thee out at Mian Mir but for me.

'Gehe mir aus dem Gesicht, oder ich schlag dich todt!--Get out of my sight, or I will kill you,' he cried.

describes that as evolving signs magnify the worth of miRs in diagnosis and prognosis of breast cancer there is still an increasing necessity for supplementary dependable "molecular markers" as the perfect indicator of disease.

The hypermethylation of CpG islands located around miR genes is a key mechanism of epigenetic downmodulation of miRs that acts as a tumor suppressor in specific tumors.

The microRNA let-7c targets the TGF-beta and the WNT1 signaling pathway and can enhance the function of the other miRs [43].

[3] Nonstandard abbreviations: CVD, cardiovascular disease; miRNA, miR, microRNA; nt, nucleotide; mRNA, messenger RNA; CAD, coronary artery disease; TVS, Tampere Vascular Study; oxLDL, oxidized LDL; VSMC, vascular smooth muscle cell; pri-miRNA, primary miRNA; DGCR8, Drosha and Di George syndrome critical region gene region 8; pre-miRNA, precursor miRNA; PAZ, Piwi, Argonaute, and Zwille; RISC, RNA-induced silencing complexes; UTR, untranslated region; siRNA, short interfering RNA; VEGF, vascular endothelial growth factor; ROS, reactive oxygen species; PBMC, blood peripheral mononuclear cells; LITA, left internal thoracic artery.

Given the growing importance of miRs, it is of high interest to determine whether measurements of the amount of miR deregulation can help to classify breast carcinomas and provide prognostic information.

More specifically, miR-26a, miR-126, miR-139, miR-140, miR-150, miR-203, miR-424, miR-503, miR-505, miR-542, miR-30e, miR-33b, miR-365, miR-758, miR-22, and miR452 were the miRs of interest in hemangiosarcoma pathogenesis (GRIMES et al., 2016).