isatin

Isatin is one of the most important derivatives of indole with significant bioactive scaffold, containing double adjacent carbonyls with an indole unit and a y-lactam moiety, which endows isatin with an amount of interesting synthetic applications [5].

Cavus, Some molecular properties and reaction mechanism of synthesized isatin thiosemicarbazone and its zinc(II) and nickel(II) complexes, Int.

The synthetic strategy for the synthesis of imines 8a-g has been described in the Scheme 3, involves reaction of acid hydrazide 1 with thiosemicarbazide to give first on a product it is 1-((5-amino-1,3,4-thiadiazol-2-yl)methyl)-3H-benzo[f]chromen-3-one 7, which is considered as starting material for the synthesis of imines 8a-f and 8g by its reaction with substituted aldehydes or isatin as shown in Scheme 3.

Quraishi, "Adsorption and inhibitive properties of some new Mannich bases of Isatin derivatives on corrosion of mild steel in acidic media," Corrosion Science, vol.

Isatin (indoline-2,3-dione) is synthetically versatile substrate serving as raw material for drug synthesis that can be modified into various heterocyclic compounds including Indoles and Quinolones [10].

Fassihi, "QSAR study of isatin analogues as in vitro anti-cancer agents," European Journal of Medicinal Chemistry, vol.

This plant gathers medicinal importance due to the presence of eugenol, fernesol, nerol, tryptanthrine, indigo, indirubin, isatin, linoleic acid, [alpha]- and [beta]-amirins, carotenoids, sterols, phenolic compounds, rutin, quercetin, kaempherol, famaricetin, luteolin, saponin, alkaloids, terpenoids, tannins, triterpenoids, anthocyanin, flavonoids, steroids, anthraquinones, citric acid, tartaric acid, couroupitine, and pelargonidin glycosides [6-8].

Wang, "Effect of isatin on the activities of antioxidase in PD model mice," China Pharmacy, vol.