Microbial conversion of choline to trimethylamine requires a
glycyl radical enzyme.
Glycyl tRNA synthetase mutations in Charcot-Marie-Tooth disease type 2D and distal spinal muscular atrophy type V.
The most common is Jo-1 (histidyl) (15%-30% prevalence), followed by PL-7 (threonyl) and PL-12 (alanyl), with a prevalence of 5% to 10%, followed by EJ (
glycyl), OJ (isoleucyl), KS (asparaginyl), Zo (phenylalanyl), and YRS (tyrosyl) (all with prevalences of 1%-5%).
Interestingly, amongst the seven genes that have been identified to cause the disease, most have housekeeping functions, including small heat shock proteins (sHSP) (dHMN-II);
glycyl tRNA synthetase (GARS) (dHMN-V); Berardinelli-Seip congenital lipodystrophy (BSCL2) (dHMN-V); immunoglobulin [micro]-binding protein-2 (IGHMBP2) (dHMN-VI); dynactin (DCTN1) (dHMN-VII); and senataxin (SETX) (dHMN) with pyramidal tract signs.
Arginyl
glycyl aspartic acid (RGD) was bound to PEG to form a hydrogel that facilitated the survival, the neuronal differentiation of NSCs, and the growth and extension of neurites [99].
Characterization of cholinetrimethylamine-lyase expandsthe chemistry of
glycyl radical enzymes.
The top row here has
GLYCYL (Webster's Third) as the longest typable word.
Finally, SizeOn Maximum Performance contains a blend of electrolytes: sodium glycerophosphate, calcium glycerophosphate, potassium glycerophosphate, and the amino acids L-taurine, L-alanyl-L-glutamine, and magnesium
glycyl glutamine.