To develop rugged and appropriate LC method for separation and quantification of the metabolite of venalafaxine HCl, different mobile phases, stationary phases (C18, C8,
Cyano, and silica) were evaluated.
However, it is clear that in the P1 structure the intermolecular distance between the
cyano groups in neighbouring molecules in the [011] direction is too short (2.45(4) [Angstrom]).
Compound 4 was subjected to a standard procedure of transforming the
cyano group into amidine via thioimidate salt [7], that is nitrile 4 was reacted with hydrogen sulphide affording thioamide 5, which was converted to thioimidate salt 6 with methyl iodide.
Type A: Normal phase (Silica,
Cyano (CN), Diol and amino (N[H.sub.2])).
attribute the signal to the
cyano group of isocyanate, thiocyanate, and isothyocianate related to degradation products of protein [14].
1-(4-((1H-imidazol-2-yl)sulfonyl)phenyl)ethanone (ISE) and
cyano acetic acid hydrazide were synthesized based on the method reported in literature [16].
The IR spectrum showed a strong absorption band at 1732 [cm.sup.-1] corresponding to lactonic carbonyl group and the disappearance of the
cyano group.
Polymerization occurs through the
cyano groups on phthalonitrile units by an addition mechanism to afford the heterocyclic cross-linked products such as polytriazine, polyimine, and polyphthalocyanine, which ensures that these materials possess excellent thermal and oxidative stability [2, 11-13].
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This is particularly the case for the polar
cyano mesogen in Figure 1 where liquid crystal phases appear in the elastomer that did not exist before cross-linking [10].