When first insect and mammalian PGRPs are cloned in 1998, it is noticed that they all contain an
amidase homology domain (Brownell et al., 2016).
Besides, isoniazid is also hydrolyzed by
amidase to toxic hydrazine.
Moreover, these DEGs have 399 molecular functions (Figure S1B) wherein hydrolase, transport protein, transmembrane transporter activity, transferase activity,
amidase transmembrane transporter, transcription factor activity, and efflux transmembrane transporter activity may be related to multidrug resistance in the MDR isolate strain of C.
The regulation of AmpC production has been historically understood to require three proteins: AmpG, a plasma membrane-bound permease; AmpD, a cytosolic peptidoglycan-recycling
amidase; and AmpR, the transcriptional regulator of AmpC.
ampD encodes a cytosolic N-acetyl-anhydromuramyl-L-alanine
amidase and specifically hydrolyzes the 1,6-anhydro-MurNAc peptide, thus inhibiting the ampC expression [11, 12].
Graber, "
Amidase activity and thermal-stability of human thrombin," Applied Biochemistry and Biotechnology, vol.
Bacillus megaterium, a mesophilic bacterium, has been known as the important industrial microorganism for producing penicillin
amidase, amylase, glucose dehydrogenase, and fungicidal and antiviral agents for a long time.
The lipoic acid bound to the food proteins and can be released by an intestinal
amidase. Some bacteria encode an
amidase called lipoamidasa capable of releasing lipoic acid from the intact 2-oxo acid dehydrogenase complexes.
Identification of
Amidase negative strains of Bacillus thuringiensis.
Trypsin
amidase activity was evaluated according to Erlanger et al.