The most common is Jo-1 (histidyl) (15%-30% prevalence), followed by PL-7 (threonyl) and PL-12 (
alanyl), with a prevalence of 5% to 10%, followed by EJ (glycyl), OJ (isoleucyl), KS (asparaginyl), Zo (phenylalanyl), and YRS (tyrosyl) (all with prevalences of 1%-5%).
Mohmmed, "Synthesis, anti-Inflammatory, Analgesic, Molecular Modeling and ADMET Studies of Novel Diclofenac Derivatives Containing
Alanyl Moiety," Chemistry and Materials Research, vol.
2ROX) indicates a binding orientation in which the
alanyl moiety of [T.sub.4] facilitates hydrogen bonding interactions with Lys15 and Glu54, and the phenol is oriented towards Ser117 and Thr119 (Wojtczak et al.
In the context of malaria transmission, recent evidence suggests that Plasmodium parasites use multiple mosquito midgut molecules as adhesion ligands, which include glycans (carbohydrates) (22-24) and enzymes such as
alanyl aminopeptidase (APN).
DPP-IV, an enzyme located mainly on endothelial cells and in circulation, preferentially cleaves N-termini with either prolyl or
alanyl residues in the second position (63).
The gut showed highest activities of
alanyl aminopeptidase, dipeptidyl aminopeptidase (DAP) I, II and IV, and cathepsin B, L and H while head showed highest activities of arginyl, leucyl and tripeptidyl aminopeptidase.
-- The structure of 1,2-Benzo-8-(
Alanyl)-3-Phenoxazone was determined by use of heteronuclear single quantum coherence (HSQC) and heteronuclear multiple bond coherence (HMBC).
The other proteins which were identified in high molecular weights region were Oma87 (PM1992),
Alanyl tRNA ligase, and ligand-gated channel proteins.
Thus
alanyl aminopeptidase was increased by 53%, arginyl aminopeptidase by 73%, leucyl aminopeptidase by 16%, dipeptidyl aminopeptidase IV by 17%, tripeptidyl aminopeptidase by 148% and proline endopeptidase by 111%.